Long‐term potentiation (LTP) of excitatory synapses is a leading model to explain the concept of information storage in the brain. Multiple mechanisms contribute to LTP, but central amongst them is an increased sensitivity of the postsynaptic membrane to neurotransmitter release. This sensitivity is predominantly determined by the abundance and localization of AMPA‐type glutamate receptors (AMPARs). A combination of AMPAR structural data, super‐resolution imaging of excitatory synapses, and an abundance of electrophysiological studies are providing an ever‐clearer picture of how AMPARs are (...) recruited and organized at synaptic junctions. Here, we review the latest insights into this process, and discuss how both cytoplasmic and extracellular receptor elements cooperate to tune the AMPAR response at the hippocampal CA1 synapse. (shrink)

The world passed the halfway point of oil supply in 2005. World demand for oil likely will severely outstrip supply in 2008, leading to increasingly higher oil prices. Consequences are likely to include increasing gasoline prices, rapidly increasing inflation, and subsequently a series of increasingly severe recessions followed by a worldwide economic depression. Consequences may include, particularly in industrialized countries such as the United States, massive unemployment, economic collapse, and chaos.

This article reexamines the classical distinction between professional and organizational work orientations for the case of engineers. Based on data from a survey questionnaire mailed to a sample of 800 engineers in the Rochester, New York, area in 1986, it argues that the two orientations are not opposites. Instead, it is possible to score high on measures of both orientations, or to score low on both. The result is a more complex, fourfold typology of engineers' work orientations. This fourfold typology (...) is then applied to the analysis of engineers' job satisfaction. The most important finding is that the content of engineers' work—that is, the level of challenge and the intrinsic interest of the work—is the central predictor of their satisfaction. The results thus support the conjecture that contemporary engineers have become highly focused—perhaps overly focused—on the gratifications derived from technical work as a process. (shrink)

Light effects on the activity of several genes have recently been exploited in studies of plant gene expression. We discuss here some examples involving nuclear genes of higher plants, with emphasis on responses mediated by the phytochrome system. Recent work has revealed considerable diversity in the responses of different genes, indicating that several different regulatory programs are probably involved. A start has been made in studies of nuclear events associated with the changes in expression. Transcriptional regulation almost certainly occurs, although (...) many details remain to be studied and effects on mRNA processing and turnover have not been ruled out. Recent in vitro mutagenesis and gene transfer experiments with the gene for the small subunit of RuBP carboxylase indicate that sequences involved in regulating the level of expression in the light are located 5′ to the gene within about 1 kb of the start of transcription. (shrink)

Ethical training in graduate programs is an important part of the professional development process. Such training has taken a position of prominence in both counseling and clinical psychology but seems to be lagging behind in the field of sport psychology. A debate exists about whether such training is necessary and, if so, how it should be provided. An important step in better understanding these issues is to identify how such training is currently taking place. This study surveyed the program directors (...) of sport psychology programs listed in the Directory of Graduate Programs in Applied Sport Psychology about the ethical training that takes place in their programs and their perceptions of the preparedness of the students in their programs. Of those contacted, 54% responded to the e-mail based survey. The results from these respondents indicated that 64.4% of programs require training in ethics and that the training was most commonly integrated into other nonethics courses. Overall, respondents did not feel as if students were completely prepared for either the ethical or legal issues that they will face in their professional careers. The importance of ethical training and suggestions for improving ethical training are discussed. (shrink)

Ethical training in graduate programs is an important part of the professional development process. Such training has taken a position of prominence in both counseling and clinical psychology but seems to be lagging behind in the field of sport psychology. A debate exists about whether such training is necessary and, if so, how it should be provided. An important step in better understanding these issues is to identify how such training is currently taking place. This study surveyed the program directors (...) of sport psychology programs listed in the Directory of Graduate Programs in Applied Sport Psychology (Burke, Sachs, & Schrader, 2002) about the ethical training that takes place in their programs and their perceptions of the preparedness of the students in their programs. Of those contacted, 54% (n = 47) responded to the e-mail based survey. The results from these respondents indicated that 64.4% of programs require training in ethics and that the training was most commonly integrated into other nonethics courses. Overall, respondents did not feel as if students were completely prepared for either the ethical or legal issues that they will face in their professional careers. The importance of ethical training and suggestions for improving ethical training are discussed. (shrink)

Background: Clinical genomic implementation studies pose challenges for informed consent. Consent forms often include complex language and concepts, which can be a barrier to diverse enrollment, and these studies often blur traditional research-clinical boundaries. There is a move toward self-directed, web-based research enrollment, but more evidence is needed about how these enrollment approaches work in practice. In this study, we developed and evaluated a literacy-focused, web-based consent approach to support enrollment of diverse participants in an ongoing clinical genomic implementation study. (...) Methods: As part of the Cancer Health Assessments Reaching Many (CHARM) study, we developed a web-based consent approach that featured plain language, multimedia, and separate descriptions of clinical care and research activities. CHARM offered clinical exome sequencing to individuals at high risk of hereditary cancer. We interviewed CHARM participants about their reactions to the consent approach. We audio recorded, transcribed, and coded interviews using a deductively and inductively derived codebook. We reviewed coded excerpts as a team to identify overarching themes. Results: We conducted 32 interviews, including 12 (38%) in Spanish. Most (69%) enrolled without assistance from study staff, usually on a mobile phone. Those who completed enrollment in one day spent an average of 12 minutes on the consent portion. Interviewees found the information simple to read but comprehensive, were neutral to positive about the multimedia support, and identified increased access to testing in the study as the key difference from clinical care. Conclusions: This study showed that interviewees found our literacy-focused, web-based consent approach acceptable; did not distinguish the consent materials from other online study processes; and valued getting access to testing in the study. Overall, conducting empirical bioethics research in an ongoing clinical trial was useful to demonstrate the acceptability of our novel consent approach but posed practical challenges. (shrink)

Drawing on a landscape analysis of existing data-sharing initiatives, in-depth interviews with expert stakeholders, and public deliberations with community advisory panels across the U.S., we describe features of the evolving medical information commons. We identify participant-centricity and trustworthiness as the most important features of an MIC and discuss the implications for those seeking to create a sustainable, useful, and widely available collection of linked resources for research and other purposes.

This book is a collection of secondary essays on America's most important philosophic thinkers—statesmen, judges, writers, educators, and activists—from the colonial period to the present. Each essay is a comprehensive introduction to the thought of a noted American on the fundamental meaning of the American regime.

Men often make riskier decisions than women across a wide range of real-life behaviors. Whether this sex difference is accentuated, diminished, or stable under stressful conditions is, however, contested in the scientific literature. A critical blind spot lies amid this contestation: Most studies use standardized, laboratory-based, cognitive measures of decision making rather than complex real-life social simulation tasks to assess risk-related behavior. To address this blind spot, we investigated the effects of acute psychosocial stress on risk decision making in men (...) and women using a standardized cognitive measure and a novel task that simulated a real-life social situation. Participants were exposed to either an acute psychosocial stressor or an equivalent control condition. Stressor-exposed participants were further characterized as high- or low-cortisol responders. Results confirmed that the experimental manipulation was effective. On the IGT, participants characterized as low-cortisol responders made significantly riskier decisions than those characterized as high-cortisol responders. Similarly, in the online chatroom, participants characterized as low-cortisol responders were, relative to those in the Non-Stress group, significantly more likely to make risky decisions. Together, these results suggest that at lower levels of cortisol both men and women tend to make riskier decisions in both economic and social spheres. (shrink)

The ICD-11 personality disorder model is the first fully dimensional assessment of personality pathology. It consists of a personality disorder dysfunction-severity dimension, which encompasses both self- and interpersonal dysfunction, and six optional qualifiers for five prominent personality traits—Negative Affectivity, Detachment, Dissociality, Disinhibition, and Anankastia —plus a borderline pattern that is defined by the criteria of DSM-IV borderline PD. This article reports on the development of a new self-report measure to assess self- and interpersonal dysfunction and the five trait qualifiers. It (...) is the first comprehensive measure of the ICD-11 PD model in that it is the only one to include both PD dysfunction-severity as well as trait scales and because it is based on the Clinical Description and Diagnostic Guidelines, which are more detailed than the “statistical” model description that is currently on the ICD-11 website. The authors wrote 992 items and then reduced the pool to 300 items by eliminating redundancy and selecting the consensus best few items for each subconstruct. Data were collected using an online sample of 383 Prolific workers. Using exploratory factor analysis, seven domain scales were developed, each of which contained two to four scales assessing components of the domain. These preliminary scales’ psychometrics were excellent, as were the domains’ and their components’ convergent and discriminant validity, with a few generally minor exceptions. Structural analyses at the component level revealed a three-factor structure consisting of two moderately correlated Internalizing factors, one centered on Self Dysfunction with two NA components and a DSN component and the other on Interpersonal Dysfunction with DET and ANK components; as well as an Externalizing factor with DSL and a DSN component that was uncorrelated with the other two factors. Two aspects of the results in particular are striking: ANK was not the opposite end of a DSN dimension, but rather contributed to an Internalizing Interpersonal Dysfunction dimension and DSN had both an Internalizing and an Externalizing component. Implications of the findings and study limitations are discussed. (shrink)

Biological evolution provides a creative fount of complex and subtle adaptations, often surprising the scientists who discover them. However, because evolution is an algorithmic process that transcends the substrate in which it occurs, evolution’s creativity is not limited to nature. Indeed, many researchers in the field of digital evolution have observed their evolving algorithms and organisms subverting their intentions, exposing unrecognized bugs in their code, producing unexpected adaptations, or exhibiting outcomes uncannily convergent with ones in nature. Such stories routinely reveal (...) creativity by evolution in these digital worlds, but they rarely fit into the standard scientific narrative. Instead they are often treated as mere obstacles to be overcome, rather than results that warrant study in their own right. The stories themselves are traded among researchers through oral tradition, but that mode of information transmission is inefficient and prone to error and outright loss. Moreover, the fact that these stories tend to be shared only among practitioners means that many natural scientists do not realize how interesting and lifelike digital organisms are and how natural their evolution can be. To our knowledge, no collection of such anecdotes has been published before. This paper is the crowd-sourced product of researchers in the fields of artificial life and evolutionary computation who have provided first-hand accounts of such cases. It thus serves as a written, fact-checked collection of scientifically important and even entertaining stories. In doing so we also present here substantial evidence that the existence and importance of evolutionary surprises extends beyond the natural world, and may indeed be a universal property of all complex evolving systems. (shrink)

The excellent quality and depth of the various essays make [the book] an invaluable resource....It is likely to become essential reading in its field.—CHOICE.

Flesh of My Flesh is a collection of articles by today's most respected scientists, philosophers, bioethicists, theologians, and law professors about whether we should allow human cloning. It includes historical pieces to provide background for the current debate. Religious, philosophical, and legal points of view are all represented.

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Descartes on the Human Soul: Philosophy and the Demands of Christian DoctrineRichard A. WatsonC. F. Fowler. Descartes on the Human Soul: Philosophy and the Demands of Christian Doctrine. International Archives of the History of Ideas, 160. Dordrecht: Kluwer Academic Publishers, 1999. Pp. xiii + 438. Cloth, $168.00.As Defender of the Faith, René Descartes wrote his Meditations to fulfill the request of the Fifth Lateran Council in 1513 "to (...) support with rational demonstrations the Church's teaching on the immortality of the soul" (28). This allowed him to dedicate the Meditations to the Faculty of Theology at the Sorbonne in hopes of obtaining their approbation. The Faculty remained silent, but Descartes could interpret this as consent, although he removed from later editions the notice of approbation. What the Council asked for were demonstrations of the immortality of the soul and of the substantial union of the soul with the body.Mersenne thought the Meditiations were going to provide these demonstrations, so he included in the title of the first edition the promise to demonstrate the immortality of the soul, but in later editions Descartes changed this to a promise to demonstrate the distinction between the human soul and the body, or that the soul is an independent substance that is not destroyed by the death of the body, and so can be immortal. Independent substancehood does not prove that the soul is immortal, however, for Descartes agreed that God can destroy the soul at any time. This conclusion greatly bothered Mersenne and Arnauld. As for the absolute separation of the soul from the body, Descartes was criticized for supporting the Platonic doctrine of their absolute separation, making it impossible to demonstrate that the union between soul and body is substantial and not accidental. And "the central Christian doctrines of the Creation, Incarnation, Redemption, and Resurrection required a union of body and soul much more intimate than that of agent and instrument" (310). But all that Descartes's proof supports is the Platonic model of a sailor piloting a ship. Never mind that Descartes adamantly denies that the soul sits in the body thus—for the soul in union with the body feels the body as the sailor does not feel the ship—his friends and foes alike saw that the absolute difference of soul and body made their substantial union inexplicable. It also goes against the Aristotelian view of the Council of Vienne in 1311-1312 that "defined the rational soul as the forma corporis" (310). It is exactly this view that Descartes opposed by eliminating substantial forms from his philosophy.Arnauld warned Descartes about these problems, while Gassendi, Hobbes, and others attacked him. In response, Descartes expanded his views without altering them, and complained about being misunderstood. The Jesuit Father Bourdin's attacks hurt him most, for as he told Mersenne, this made him think that all the Jesuits (they stick together) were against him. This, Fowler argues, is why Descartes dedicated the Meditations to the Faculty of the Sorbonne, and not to the Jesuits.Fowler carefully presents the entire sweep of Descartes's ideas and arguments concerning the immortality of the soul and its union with the body. Descartes in fact did not manage to demonstrate either one. He did agree that of the three sorts of truths—those known by revelation alone, those known both by revelation and demonstration, and those known only by demonstration—these points about the soul belong in the middle category. But he never mentions immortality in the Meditations, and when Princess Elisabeth faces him with his inability to explain how the soul and body [End Page 120] can interact, he just says that we experience it. Gassendi asked him the same question, but Descartes ignored him. With other critics, he shifted the question into the first category of truths—it is a matter of revelation. This was not satisfactory either to his critics or to Descartes, for it had led Pompanazzi to materialism, and it led Descartes's first disciple Regius to say bluntly that metaphysics, and in particular Descartes's metaphysics, is irrelevant to the third category of truths, those of mechanics, physics, and medicine.Baillet calls... (shrink)

We argue that all comparative expressions in natural language obey a principle that we call Comparability: if x and y are at least as F as themselves, then either x is at least as F as y or y is at least as F as x. This principle has been widely rejected among philosophers, especially by ethicists, and its falsity has been claimed to have important normative implications. We argue that Comparability is needed to explain the goodness of several patterns (...) of inference that seem manifestly valid, that the purported failures of Comparability would have absurd consequences, and that the influential arguments against Comparability are less compelling than they may have initially seemed. (shrink)

1. The problemLewis identifies the monadic property being F with the set of all actual and possible Fs; the dyadic relation R is identified with the set of actual and possible pairs of things that are related by R; and so on . 1 Egan has argued that the fact that some properties have some of their properties contingently leads to trouble: " Let @ be the actual world, in which being green is [someone's] favourite property, and let w be (...) a world in which being green is [nobody's] favourite property. Since being green is somebody's favourite property in @, it must be a member of … being somebody's favourite property. Since being green is not anybody's favourite property in w, it must not be a member of being somebody's favourite property. Contradiction. " Egan suggests identifying properties with functions from worlds to extensions. However, as Lewis and others have complained, this has the drawback of turning monadic properties into relations . 2 In this article, we shall show that the Lewisian has the resources to block the above argument while simultaneously respecting the adicity of the relevant property and the contingency of the predication without changing his theory of properties. However, our analysis reveals a hidden ambiguity in the Lewisian conception of properties, and on either disambiguation the resulting account of properties seems inadequate.2. On ‘being someone's favourite property’The phrase ‘ being someone's favourite property’ is ambiguous. Given Lewis's ontology of possibilia, where the phrase picks out a monadic property it is not one that is possessed contingently; where it picks out a property that is possessed contingently it is not one that is monadic. But the argument works only if being someone's favourite property is both monadic and possessed contingently.Why should …. (shrink)

Researchers and non-commercial institutions negotiate complex legislation and guidance when planning and conducting research studies. The documents and processes required differ across nations and their regulatory bodies and it can be challenging to conduct an international study, especially for non-commercial organisations. In this study, colleagues from Japan and the UK worked closely together focusing on the legislation, organisations, trial processes, ethics review and quality assurance frameworks of clinical trials in two countries, the UK, demonstrated on the model of practices in (...) the University of Bristol and University Hospital Bristol NHS Foundation Trust, and Japan, based on the model in Kyoto University Hospital. Although the ICH tripartite guidelines were developed with participation from both the EU and Japan the set-up and approval processes for clinical trials are different between the two countries while the expectations for quality assurance are similar. We will argue that the f... (shrink)

The British have often denied the very existence of a tradition of English literary theory. George Watson redeems that denial in his latest book, the first study of 20th Century English theory. The book begins with Yeats, Pound and Eliot, who made England their home. In subsequent chapters, based on personal recollection as well as published sources, it assesses the contribution of I.A. Richards, William Empson, F.R. Leavis, C.S. Lewis, Isaiah Berlin and Wittgenstein, as well as Marxists like E.P. (...) Thompson and Raymond Williams. English literary theory is a tradition that has suffered in reputation, paradoxically, by the sheer fertility of its invention. In this seminal work the author celebrates that fertility from the First World War downto the death of Iris Murdoch in 1999, showing that England pioneered the academic study of theories of literature years in advance of France or the USA. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Mother Earth, Mother City:Abjection and the AnthropoceneJanell WatsonIf the term “Anthropocene” designates the global influence of the human species over its terrestrial habitat, then its arrival profoundly changes a number of relations that have long occupied Western philosophy: that between humans and animals; between humans and nature; and between humans and their technologies. The possibility that humans have transformed not only the biology but also the geology of the (...) earth brings to the forefront the physical world, whose corporeal materiality was all but ignored by mid-twentieth-century continental philosophy, focused almost exclusively on language and politics. As Michel Serres put it in 1990, “Our a-cosmic philosophies, for almost half a century now, have been holding forth only on language or politics, writing or logic” (1995b, 29). Technicians and scientists have created a new world, observes Serres, while philosophers act as if they still live in the old one (2001, 4). By the time Paul Crutzen and Eugene F. Stoermer formally introduced the term “Anthropocene” in 2000 (Crutzen and Steffen, 2003), Serres had developed a philosophy for the new human-dominated techno-scientific world. It is true that the physical world has in the meanwhile reappeared in continental philosophy thanks to object-oriented philosophy and various new materialisms, but Serres was among the first to formulate into a philosophical question the human impact on the physical and biological earth (2014, 63). He may well have been the very first to develop a philosophy of pollution. Serres complains that Plato, one of the few Western philosophers to even mention detritus, excludes residue and waste from metaphysics (2001, 185). Garbage, atmospheric emissions, and toxic waste not [End Page 269] only threaten life, but are also transforming biological and geological features of the earth. The philosophical dimension of pollution will be the topic of my paper.Philosophy has remained silent on this question of waste, with the notable exception of Julia Kristeva, whose theory of abjection brought the body and its discharges back into philosophy at the height of the linguistic turn. Although she presents abjection as a psychic formation, she derives the notion from the physical reaction of repugnance, vomiting, retching, and turning away when confronted with “filth, waste, or dung” and “defilement, sewage, and muck” (1982, 2). Both Serres and Kristeva portray pollution and abjection as remainders left behind by a subject-object dialectic that positions (male) humans as subjects, and everything else (and everyone) as objects to be mastered and appropriated. They both locate this oozing dialectic in Plato’s semiotic khôra, the mother’s womb. Read together, these philosophers of pollution expose the “materialist foundation” of “dialectical logic” by way of the maternal body (Kristeva 1984, 15). Kristeva focuses on the mother in order to demonstrate a corporeal basis for language and subjectivity. Although he shares the view that language comes from the body, Serres celebrates the womb as the first human habitat. He emphasizes the maternal functions of the earth: neonatal incubator, nurturer, habitat.However, waxing poetic about the sea, the riverside, and the wilderness, Serres writes very little about cities, even though they are the preferred human habitat of the new epoch. I therefore extend his reflections on human habitation in the Anthropocene epoch by considering the maternal aspects of the global megalopolis, which simultaneously sustains domestic life and produces deadly pollution. The maternal functions of reproduction, nourishment, and shelter are pushing the limits of the earth’s physical capacities. Maternity thus lies at the heart of the problem of the Anthropocene: the possibility that human domination of the earth will deplete its ability to sustain life.MatrixAlthough he grounds his philosophy in complexity, chaos, narrative, and anthropology, in his 1990 manifesto, The Natural Contract, Serres argues that science and technology have brought about a subject-object reversal between the human species and the earth (1995b). He bases his argument on a dialectical model in order to expose a struggle for domination, the classical confrontation between master and slave. Serres credits Descartes with foreseeing from his vantage point at the dawn of the scientific age that humans would go on to “dominate and appropriate” the natural world according... (shrink)

The potential for the occurrence of multiple-role relationships is increased when professors also consult with athletic teams on their campuses. Such multiple-role relationships have potential ethical implications that are unclear and largely unexplored, and consultants may find multiple-role relationships both difficult to deal with and unavoidable. Therefore, the purpose of this study was to explore the nature of teacher-practitioner multiple-role relationships. Participants (N=35) were recruited from Association for the Advancement of Applied Sport Psychology (AAASP) certified consultants (CCs) who were also (...) affiliated with a university (N=68). All participants completed a 28-item survey exploring the incidence and relevant issues pertaining to multiple-role relationships. Chi-square analyses revealed that licensed mental health practitioners (i.e., psychologists and counselors) were more likely than nonlicensed AAASP CCs to believe that multiple-role relationships were never appropriate in sport psychology, ?²(1,N= 30) = 12.80, p <.001, and to have never taken part in a multiple-role relationship, ?²(1, N= 33) = 12.44, p<.001. Independent samples t tests revealed that mental health practitioners also reported that they would have higher levels of concern for both the practitioner, r(30) = -2.77, p = .009, and the client, f(30) = -2.50, p = .018, in such a relationship. (PsycINFO Database Record (c) 2008 APA, all rights reserved). (shrink)